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點擊化學 Alkynyl Palmitic Acid

更新(xin)時間:2022-07-28

簡要描述:

點擊化學 Alkynyl Palmitic Acid:
Alkynyl Palmitic Acid 是(shi)一(yi)種 PROTAC linker,屬于(yu)(yu) alkyl chain 類。可用于(yu)(yu)合成(cheng) PROTAC 分子。Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PR

點擊化學 Alkynyl Palmitic Acid

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炔基(ji)肉(rou)豆(dou)蔻(kou)酸(suan)(suan)可用(yong)(yong)于鑒(jian)定和表(biao)征翻譯后(hou)的(de)(de)(de)肉(rou)豆(dou)蔻(kou)基(ji)化蛋白質 炔基(ji)棕(zong)(zong)櫚酸(suan)(suan)(15-十六烷(wan)酸(suan)(suan)或(huo)棕(zong)(zong)櫚酸(suan)(suan) (15-yne))是一種修飾的(de)(de)(de)棕(zong)(zong)櫚酸(suan)(suan),帶有 ω-末端(duan)炔烴。 炔基(ji)棕(zong)(zong)櫚酸(suan)(suan)通(tong)常用(yong)(yong)于使(shi)用(yong)(yong)強大(da)的(de)(de)(de)點擊化學識別和表(biao)征蛋白質的(de)(de)(de)翻譯后(hou) S-棕(zong)(zong)櫚酰(xian)化。.

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry (see References).

結構式 :

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部分產品的詳細列表:Click chemistry tools授權代理

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參考文獻

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.


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