精品久久久无码21P发布_国产V亚洲V天堂无码_车上震动A级作爱视频_国产精品成熟老妇女

技術文章您現在的位置:首頁 > 技術文章 > Broadpharm什么是輔助脂質Helper Lipid?

Broadpharm什么是輔助脂質Helper Lipid?

更新時間:2022-11-12   點擊次數:120次

What is a Helper Lipid?

Helper Lipids are a class of lipid molecules that increase particle stability and fluidity of lipid nanoparticles (LNP). Several classes of molecules were used as helper lipids such as phospholipids as exemplified by DSPC (Figure 1), cholesterol, PEGylated lipid.


Figure 1: Structure of DSPC


Benefits of Helper Lipids?

The main benefits using Helper lipids in Lipid nanoparticles (LNPs) delivery vehicles is to improve the properties of the nanoparticle, such as particle stability, delivery efficacy, tolerability and biodistribution.

For example, cholesterol can enhance particle stability by modulating membrane integrity and rigidity. The molecular geometry of cholesterol derivatives can further affect delivery efficacy and biodistribution of lipid nanoparticles. cholesterol analogues with C-24 alkyl phytosterols increases the in vivo delivery efficacy of lipid nanoparticle-mRNA formulations.

Helper lipids with a cone-shape geometry favoring the formation hexagonal II phase, such as dioleoyl phosphatidylethanolamine (DOPE), can promote endosomal release of ONs.

Cylindrical-shaped lipid phosphatidylcholine can provide greater bilayer stability, which is important for in vivo application of LNPs.

PEGylated lipids (PEG lipids) can enhance LNP colloidal stability and circulation time in vivo, but it might reduce uptake and inhibit endosomal release at the cellular level. This problem can be addressed by choosing reversible PEGylation in which the PEG moiety is gradually released in blood circulation.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research. 

Journal Reference:

1. X Cheng, R. Lee, The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery, Adv Drug Deliv Rev, PMID: 26900977

靶點科技(北京)有限公司

靶點科技(北京)有限公司

地址:中關村(cun)生命科學園北清(qing)創意園2-4樓2層

© 2023 版權所有:靶點科技(北京)有限公司    總訪問量:190667  站點地圖  技術支持: