精品久久久无码21P发布_国产V亚洲V天堂无码_车上震动A级作爱视频_国产精品成熟老妇女

技術文章您現在的位置:首頁 > 技術文章 > BroadPharm什么是陽離子脂質Cationic Lipids?

BroadPharm什么是陽離子脂質Cationic Lipids?

更新時間:2022-11-12   點擊次數:90次

What are Cationic Lipids?

Cationic lipids are a class of lipid molecules with a permanent positive charged head group with structure as exemplified by molecule DOTAP (Figure 1). Because of the structure specialty, Cationic lipid are an amphiphilic entity with a head group having hydrophilicity and lipid tails possessing hydrophobicity.


Figure 1: Structure of DOTAP


Application of Cationic Lipid

The first publication about Cationic lipids to transfect DNA into cells was published by Philip Felgner. Currently, Cationic lipids have become one of few major class of molecules in lipid nanoparticle (LNP) drug delivery vehicles, mRNA vaccine encapsulation. Cationic lipids neutralize negative charges and facilitate encapsulation and cell uptake in lipid nanoparticles (LNP). Usually unsaturated, short (<30 monomer) hydrocarbon chains of the lipids are associated with the highest transduction efficiencies. In aqueous environments, these lipids form micelles with positively charged surfaces that complex with DNA. These lipoplexes act to neutralize charge repulsion between the cell membrane and DNA and promote endocytosis, similar to the mechanism of cationic polymers.

Lipid supplier and customer synthesis

As a leading biochemical supplier worldwide, BroadPharm offer a wide array of Lipid molecules, such as Ionizable lipids, cationic lipids, helper lipids, and PEG lipids to our clients worldwide. BroadPharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.

Journal Reference:

1. S. Simoes, A. Filipe, (March 2, 2005). "Cationic liposomes for gene delivery". Expert Opinion on Drug Delivery. 2 (2): 237-254.

2. X. Hou, T. Zaks, R. Langer, Y. Dong, "Nature Review Materials", (2021)

3. B. Pitard, D. Habrant , Supramolecular Medicinal Chemistry and Chemical Biology, in Comprehensive Supramolecular Chemistry II, 2017


靶點科技(北京)有限公司

靶點科技(北京)有限公司

地址(zhi):中關村生命科學園(yuan)北清創(chuang)意園(yuan)2-4樓2層

© 2023 版權所有:靶點科技(北京)有限公司    總訪問量:189305  站點地圖  技術支持: