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kerafast代理Anti-VSV-M [23H12] 抗體

更新時間:2021-11-19   點擊次數:907次

kerafast總代理靶點科技貨號EB0011單克隆抗體Anti-VSV-M [23H12] Antibody與VSV-M蛋白反應。


產品特色:

-與VSV-M蛋白發生反應

-適用于蛋白質印跡應用


背景介紹:

水皰性口炎病毒(VSV)是一種經過充分研究的包膜負鏈RNA病毒。VSV 基因組編碼 5 種蛋白質:N、P、M、G 和 L。G蛋白(糖蛋白)位于病毒粒子表面,負責病毒附著和滲透。此外,許多慢靜脈載體是用來自印第安納州血清型的VSV-G假分型的。


水皰性口炎病毒(VSV)是一種經過充分研究的包膜負鏈RNA病毒。VSV 基因組編碼 5 種蛋白質:N、P、M、G 和 L。M蛋白(或基質蛋白)負責結合核衣殼并將其凝聚成緊密盤繞的螺旋,并將核衣殼與包膜結合。M蛋白的這種活性使病毒具有彈狀的形狀。除了M蛋白在病毒組裝中的作用外,它還負責介導VSV發病機制的分子機制。野生M型蛋白抑制感染細胞中的宿主基因表達并抑制抗病毒反應。


Background:

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.


Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.


產品詳情:

Product Type:Antibody
Name:Anti-VSV-M [23H12]
Antigen:VSV-M
Host:Mouse
Isotype:EB0011: IgG2a kappa
Clonality:Monoclonal
Clone Name:23H12
Specificity:VSV-Ind matrix (M) protein
Reactivity:Human
Immunogen:VSV infection
Format:Liquid
Purification Method:Protein G purified
Buffer:EB0011: PBS, 0.05% (w/v) Sodium Azide
Recombinant versions: PBS with 0.02% Proclin 300
Tested Applications:Western blot (1:1000)
Concentration:1mg/mL
Amount:100uL
Storage:-20C (avoid repeated freeze / thaw cycles)
Shipped:Cold packs




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